4,103 total views
ModafinilUP.com offers a comprehensive selection of scientific research on modafinil, backed by hard data and extensive analysis.
Our website is dedicated to providing you with a detailed explanation of what modafinil is and how it can be used effectively. We cover everything from dosage recommendations to comparisons with similar drugs, helping you make informed decisions about your own health and well-being.
In addition to providing detailed information on the most effective ways to use modafinil, we also offer guidance on which brand of the drug is the best, as well as tips on where to find the most reliable online sellers. We prioritize your safety and well-being above all else, and are committed to providing the most up-to-date information on how to use modafinil safely and effectively.
Table of Contents:
- Overview and Benefits of Modafinil
- Side Effects of Modafinil
- Legality of Modafinil
- Pharmacology of Modafinil
- Buy Modafinil Online
- Best Generic Modafinil Brands
- Availability of Modafinil by Country
- History of Modafinil
- How Modafinil Works
Modafinil is a pharmaceutical drug that is most commonly known as a “eugeroic,” meaning that it promotes wakefulness and enhances alertness. In the healthcare industry, Modafinil is prescribed to treat excessive daytime sleepiness in three medical conditions: narcolepsy, shift work sleep disorder, and obstructive sleep apnea.
However, Modafinil is more commonly used off-label as a cognitive-enhancing “smart drug” or nootropic. In fact, 80% of all Modafinil prescriptions are written off-label, including for conditions such as depression, fatigue, and general sleepiness.
Millions of professionals worldwide, working in highly competitive industries that depend on high productivity and maximum performance, use Modafinil. Common professions associated with intensive Modafinil use include surgeons, Ivy League students, Silicon Valley entrepreneurs, military personnel, profitable day traders, and anyone who relies solely on knowledge-based work.
Modafinil has garnered significant media attention in the last decade, with several high-profile articles written by respected institutions . In addition, well-known authorities in the field of biohacking, have documented their positive experiences with this smart drug.
This has prompted many people to ask several questions about Modafinil: does it really do what its most evangelical supporters claim, is it safe to take this drug for an extended period, will I have legal issues due to its use, and how can I obtain it?
ModafinilUP.com was created with the sole purpose of answering every question you may have about Modafinil, backed by rigorous scientific research and reviews from experienced smart drug users.
Armodafinil is a related drug that is also used to promote wakefulness and alertness. It is considered a stronger version of Modafinil and is often used by individuals who do not experience the desired effects from Modafinil. Armodafinil is sold under the brand name Nuvigil and is available only by prescription. It is important to consult a healthcare professional before taking any medication, including Armodafinil.
Overview and Benefits of Modafinil
Modafinil’s reputation as the leading productivity-enhancing drug is not just the result of anecdotal evidence and rumors. Several scientific studies confirm the effectiveness of modafinil in relation to various mental characteristics:
- Overcoming fatigue – modafinil can significantly reduce various levels of fatigue in patients with multiple sclerosis, cancer.
- Improved memory – modafinil has been shown to improve both working memory (i.e. immediate memory) and episodic memory (i.e. unique memories of specific events) in healthy people without depression and in people with depression.
- Increased motivation – modafinil works to improve subjective well-being and overall mood in a positive direction. This has been confirmed in studies involving dopamine-depleted mice and healthy adults.
- Increased alertness – if you’re sleep-deprived or stayed up all night, modafinil can increase your alertness and restore your cognitive functions to their original level or higher.
- Longer-lasting energy – for sleep-deprived soldiers, modafinil consistently improves the ability to mentally perform tasks at an acceptable level for periods of time covering more than 35 hours of continuous wakefulness.
- Enhanced emotional processing – research suggests that modafinil may also improve emotional processing in individuals with depression and anxiety. Emotional processing involves the ability to identify, understand, and regulate one’s own emotions as well as those of others. By improving emotional processing, modafinil may help individuals with these conditions to better manage their symptoms and improve their overall well-being.
- Improved executive function – executive function refers to a set of mental processes involved in planning, organizing, and completing tasks. Studies have shown that modafinil can improve executive function in individuals with neurological disorders such as Parkinson’s disease. However, more research is needed to determine the extent to which modafinil can improve executive function in healthy individuals and those with other psychiatric disorders.
Other benefits reported by individual modafinil users include eliminating “writer’s block,” more noticeable weight loss, and less impulsiveness in relation to internal and external distractions. However, unlike the benefits mentioned above, these are purely anecdotal and not supported by scientific data.
Modafinil users may notice some of these effects, all of these effects, or none of these effects. Modafinil is one of the few nootropics whose experience of use is entirely individual due to individual biochemistry and genetic profile.
If you don’t regularly take modafinil for 1-6 months and don’t measure its impact on your cognition, any discussions about what it will and won’t do are purely speculative.
Overall, modafinil can significantly improve the personality traits and cognitive functions necessary to maintain an extremely high level of personal productivity.
Side Effects of Modafinil
Modafinil is considered one of the safest and most well-tolerated nootropics available, especially when compared to other pharmaceuticals, according to a comprehensive review by ACS Chemical Neuroscience. The review found that modafinil had fewer toxicological side effects compared to traditional psychostimulants such as amphetamines or cocaine. In animal models, modafinil was also generally well-tolerated and demonstrated very low abuse liability in non-drug abusing individuals.
However, there are some mild side effects that can be experienced by both new and experienced modafinil users, such as headaches, slightly elevated blood pressure, nausea, dizziness, anxiety, and restlessness. These effects typically dissipate with repeated use of modafinil or by abstaining from the drug altogether. It’s worth noting that tolerance to modafinil rarely develops, except in cases of overdose.
When used in appropriate doses and at the right time, modafinil has practically no side effects and is safe to use for improving cognitive function or treating its prescribed medical conditions. Responsible use is necessary to achieve the highest chances of success, as with any nootropic or pharmaceutical.
Armodafinil, the “enantiopure” version of modafinil, has the same safety profile and side effects as modafinil. Differences observed by users who have taken both nootropics are highly subjective, and to date, there are no published rigorous studies on the differences in the frequency and severity of side effects between armodafinil and modafinil with long-term use in healthy individuals who do not suffer from sleep deprivation.
Legality of Modafinil
Modafinil is classified as a Schedule IV controlled substance by the Drug Enforcement Administration in the United States and in many other countries around the world. Obtaining and using modafinil without a prescription can lead to legal consequences, as it is mainly prescribed for diagnosed conditions such as narcolepsy or sleep apnea, and obtaining a prescription for off-label uses can be difficult. While purchasing small amounts of modafinil for personal use online may not result in legal problems, selling it to others is illegal. Moreover, modafinil is prohibited in competitive sports by organizations such as WADA and USADA, and specific drug tests can detect it in urine or bloodstream several days after use. Therefore, it is important to understand the legal implications before using modafinil for any purpose.
In other countries, modafinil is similarly classified as a controlled substance, which means that obtaining and using it without a prescription can result in legal consequences. Despite its popularity as a cognitive enhancer, using modafinil for non-medical purposes or without a prescription can be risky.
Pharmacology of Modafinil
Despite extensive research, there is still no definitive answer to the exact mechanism of action of modafinil on the brain and the rest of the human body. While scientists have been able to uncover certain aspects of how modafinil works, the entire puzzle remains incomplete.
One well-known effect of modafinil is its inhibition of dopamine reuptake, which leads to increased extracellular dopamine concentrations in the brain. This does not directly increase dopamine production, but rather allows more dopamine to be available for use.
Other neurotransmitters are also believed to be involved, including increased histamine production and decreased GABA production. However, researchers have yet to identify a single site of action or determine the location of binding of the major receptors.
Modafinil also affects the activity of certain enzymes in the liver, which can impact the plasma levels of drugs metabolized by those enzymes. It has a half-life of 11-16 hours, reaches maximum concentration in the bloodstream about 2 hours after oral administration, and its pharmacokinetic properties depend on the dose.
Most of modafinil is metabolized into inactive metabolites in the liver and primarily excreted in urine. The half-life and maximum concentration of modafinil in plasma are higher in patients with renal and/or hepatic insufficiency.
Buy Modafinil Online
The number of legitimate modafinil sellers on the internet is increasing, providing buyers with the option to purchase and receive the drug in their country of residence.
A single scientific study has identified over 63 websites solely dedicated to distributing modafinil in various forms.
The benefits of purchasing modafinil online are numerous. Not only can customers obtain high-quality modafinil at a lower price, but they can also receive their desired amount of the drug quickly without needing a doctor’s prescription, which is still recommended.
Furthermore, online modafinil sellers aim to make the buying process as simple as possible for their customers.
As we will mention below, the regulatory status of modafinil varies depending on the jurisdiction. However, we do not know of any cases in the US or other countries where people have faced legal issues or been arrested for purchasing small quantities of modafinil online for personal use.
However, selling or giving away modafinil is illegal and can result in legal consequences.
Many trustworthy modafinil and nootropic suppliers are knowledgeable about the laws and jurisdictions surrounding their activities. In rare cases where a customs agent seizes an online modafinil order, customers will typically receive a refund or a reshipment of their order.
Please keep in mind that some suppliers may not ship to your country, or their delivery times may not align with your purchase criteria. As a result, you should select a supplier that ships modafinil to your country of residence.
Best Generic Modafinil Brands
Modafinil and Armodafinil are popular cognitive enhancing drugs that are sold under various brand names such as Provigil, Alertec, and Nuvigil in pharmacies. However, these drugs are also available in several generic forms, which are highly recommended for their affordability and identical composition and pharmacological effects.
Whether you choose to buy modafinil online or buy armodafinil online, you will find several popular generic brands available in the market. Among generic modafinil brands, Modalert and Modvigil are the two consistent and reliable options that have proven their quality and effectiveness. Modalert, produced by SUN Pharmaceuticals, is the most powerful and long-lasting form of generic modafinil available, while Modvigil, produced by HAB Pharmaceuticals, is a cost-effective option with similar cognitive enhancing effects that do not last as long.
Similarly, generic armodafinil is available in two popular brands: Waklert and Artvigil. Waklert, produced by SUN Pharmaceuticals, is the most potent and long-lasting form of generic armodafinil available, while Artvigil, produced by HAB Pharmaceuticals, is a cheaper alternative with less potent cognitive enhancing effects that do not last as long.
It is important to note that SUN Pharmaceuticals and HAB Pharmaceuticals are legitimate manufacturers of modafinil and armodafinil, based in India, that have been providing users with high-quality generics for several years.
Availability of Modafinil by Country
In the previous section on “Legality,” it was noted that each country has its own classification and regulations regarding modafinil. These regulations are primarily based on the evaluation of scientific data by healthcare agencies, which assess the benefits and risks of using modafinil for medical purposes.
However, it is generally understood that the majority of countries will not permit the legal purchase of modafinil without a valid prescription from a physician. Moreover, it is necessary to obtain modafinil from a legitimate pharmacy in person.
While there are certain exceptions to this rule, such as Brazil allowing the purchase of modafinil without a prescription, it is essential to understand and comply with the laws and regulations of your country regarding modafinil.
Conducting thorough research will assist you in determining whether obtaining modafinil through a prescription or purchasing it online is the best option for your particular situation.
History of Modafinil
The discovery of modafinil dates back to 1973-1974 in France, where two medical chemists working at Lafon Laboratories found adrafinil, its metabolic precursor, while searching for potential narcolepsy treatments. Due to its efficacy, lack of sedative effects, and lack of side effects commonly associated with drugs like Adderall, which contain amphetamines causing withdrawal syndrome, tremors, etc., adrafinil attracted significant attention.
Michel Jouvet, a neurophysiologist at the same company, discovered modafinil as the primary metabolite of adrafinil. Upon administering modafinil to narcolepsy patients, it was found to act more effectively and quickly than adrafinil. Modafinil was authorized in France in 1992-1993 to treat narcolepsy under the trade name Modiodal.
Cephalon, a pharmaceutical company, received an exclusive license from Lafon to manufacture modafinil in the United States. In 1998, the Food and Drug Administration (FDA) approved modafinil for treating narcolepsy under the trade name Provigil.
Provigil was approved in 2000s for treating excessive daytime sleepiness associated with obstructive sleep apnea and shift work sleep disorder. Modafinil is widely used in the military to enhance soldiers activity and alertness during sleep deprivation. Public figures such as Jon Torres and Iloon Mask have publicly recognized its usage. Athletes like Ray Benjamin and Michael Norman have confessed to using modafinil, although it is banned in sports because it is regarded as an illegal drug.
Overall, the discovery and development of modafinil represent a significant achievement in the field of sleep medicine and pharmacology, offering a safe and effective treatment for narcolepsy and other sleep disorders. However, the increasing use of modafinil as a cognitive enhancer raises ethical and practical concerns that require further research and discussion.
How Modafinil Works
Modafinil has gained an exceptional international reputation in the modern world, thanks to its remarkable effectiveness. In today’s competitive environment, where the slightest mental advantage can be the difference between winning and losing, modafinil has become the go-to smart drug for high-performing individuals seeking a dependable cognitive boost.
As a smart drug that induces boundless energy, laser-like focus, and long-term motivation, modafinil should be on everyone’s radar. Few nootropics can match modafinil’s ability to stimulate the brain while still maintaining a favorable side effect and safety profile.
The similarities between modafinil and the NZT-48 pill from the movie “Limitless” are uncanny, making it no surprise that students and writers flock to it. With the ability to tap into extreme levels of alertness and persistence, modafinil helps individuals accomplish more productive work in shorter periods of time, who wouldn’t want that?
The bottom line is clear- modafinil is highly effective, and its reputation as the top smart drug is well deserved.
- “Modafinil: A Review of Neurochemical Actions and Effects on Cognition”: https://www.ncbi.nlm.nih.gov/ Published: 22/02/2012)
- “Armodafinil for Treatment of Excessive Sleepiness”: https://www.ncbi.nlm.nih.gov/(Published: 2013)
- “Modafinil Side Effects”: en.wikipedia.org/wiki/Modafinil/ (Retrieved: 05/03/2023)
- “How to use Modafinil”: https://www.webmd.com (Retrieved: 06/03/2023)
- “Modafinil: MedlinePlus Drug Information”: https://medlineplus.gov (Last updated: 02/15/2016)
- “Modafinil Uses, Side Effects & Warnings”: https://www.drugs.com (Last updated: 13/04/2022)
- “Modafinil (Provigil): Uses, Interactions & Side Effects”: https://my.clevelandclinic.org/(Last updated: 07/03/2023)
- “Modafinil (Oral Route)”: https://www.mayoclinic.org/drugs-supplements/modafinil-oral-route/side-effects/drg-20064870?p=1 (Last updated: 01/03/2023)
- “Provigil (Modafinil): Uses, Dosage, Side Effects, Interactions”: https://www.rxlist.com/provigil-drug.htm (Last updated: 06/16/2020)
- Ferraro L, Antonelli T, Tanganelli S, O’Connor WT, Perez de la Mora M, Mendez-Franco J, et al. The vigilance promoting drug modafinil increases extracellular glutamate levels in the medial preoptic area and the posterior hypothalamus of the conscious rat: prevention by local GABAA receptor blockade. 1999.
- Ishizuka T, Sakamoto Y, Sakurai T, Yamatodani A. Modafinil increases histamine release in the anterior hypothalamus of rats. Neurosci Lett. 2003;339(2):143–146.
- Simon P, Hémet C, Ramassamy C, Costentin J. Non-amphetaminic mechanism of stimulant locomotor effect of modafinil in mice. Eur Neuropsychopharmacol. 1995;5(4):509–514
- Volkow ND, Fowler JS, Logan J, Alexoff D, Zhu W, Telang F, et al. Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. JAMA. 2009;301(11):1148–1154
- Nishino S, Mao J, Sampathkumaran R, Shelton J. Increased dopaminergic transmission mediates the wake-promoting effects of CNS stimulants. Sleep Res Online. 1998;1(1):49–61
- Schmitt KC, Reith ME. The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors. PLoS One. 2011;6(10):e25790.
- Johnson RL, Block I, Gold MA, Markwell S, Zupancic M. Effect of methylphenidate on fatigue in women with recurrent gynecologic cancer. Psychooncology. 2010;19(9):955–958.
- Prommer E. Modafinil: is it ready for prime time? J Opioid Manag. 2006;2(3):130–136.
- Makris AP, Rush CR, Frederich RC, Taylor AC, Kelly TH. Behavioral and subjective effects of d-amphetamine and modafinil in healthy adults. Exp Clin Psychopharmacol. 2007;15(2):123–133.
- Kumar R. Approved and investigational uses of modafinil: an evidence-based review. Drugs. 2008;68(13):1803–1839.
- Modafinil: A Chronology of Three Decades. Retrieved July 21, 2020. hmpharmacon.com
- Generic Drugs, Are They as Good as Brand Names? (Retrieved: 20/07/2020) medicinenet.com
- Hockenhull J, Wood DM, Dargan PI. The Availability of Modafinil and Methylphenidate Purchased from the Internet in the United Kingdom Without a Prescription. Subst Use Misuse. 2020;55(1):56-65. 10.1080/10826084.2019.1654516