Overview of Modafinil Mechanism of Action

Modafinil Mechanism of Action
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1. Dopaminergic Modulation

2. Effect on Orexin (Hypocretin) System

3. Interaction with GABAergic and Glutamatergic Systems

4. Role in Histaminergic Activity

5. Adrenergic System Activation

1. Treatment of Narcolepsy

2. Management of Obstructive Sleep Apnea (OSA)

3. Addressing Shift Work Sleep Disorder (SWSD)

References:

  1. Antonelli T, Ferraro L, et al. Modafinil prevents glutamate cytotoxicity in cultured cortical neurons. Neuroreport. 1998
  2. Ballon JS, Feifel D. A systematic review of modafinil: potential clinical uses and mechanisms of action. J Clin Psychiatry. 2006
  3. Bettendorf L, Sallanon-Moulin M, et al. Paradoxical sleep deprivation increases the content of glutamate and glutamine in rat cerebral cortex. Sleep. 1996
  4. Fuxe K, et al. Modafinil enhances the increase of extracellular serotonin levels induced by the antidepressant drugs fluoxetine and imipramine: a dual probe microdialysis study in awake rat. Synapse. 2005
  5. Mechanisms of modafinil: A review of current research. nih.gov. 2007
  6. PROVIGIL (modafinil) Tablets. FDA.GOV. 2010
  7. Oliva Ramirez A, Keenan A, Kalau O, Worthington E, Cohen L, Singh S. Prevalence and burden of multiple sclerosis-related fatigue: a systematic literature review. 2021.
  8. Ciancio A, Moretti MC, Natale A, Rodolico A, Signorelli MS, Petralia A. Personality Traits and Fatigue in Multiple Sclerosis: A Narrative Review. Journal of Clinical Medicine. 2023

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